There is some direct and indirect evidence in support of the hypothesis of IBS, which has management implications. In the presence of dysregulated gastrointestinal motor function, it is conceivable that stasis promotes small intestinal bacterial overgrowth to occur, inducing fermentation and leading to production of excess gas. The gas in turn may be trapped and induce some of the symptoms of IBS, including discomfort and bloating. Psychosocial factors do appear to be important in IBS, although whether these factors directly alter gastrointestinal function remains uncertain. It is also possible that gastrointestinal dysfunction modulates central processes.

There is good evidence now that abuse in childhood or adulthood is associated with IBS, although whether it is of aetiological importance remains in dispute. Anxiety and depression are also common in IBS. Some have conceptualized IBS as a somatization disorder, but the clear evidence for an organic pathophysiology makes this unlikely. There are differences in brain responses in patients with IBS that have been documented. For example, measures of regional cerebral blood flow during rectal distention have shown that IBS patients have greater activation of the anterior cingulate cortex, amygdala and dorsomedial frontal cortex, in contrast to patients with ulcerative colitis and controls.

It has been supposed that the brains of people without IBS are better able to activate endogenous pain inhibition areas. This could represent a genetic predisposition to IBS. The antidepressant amitriptyline has been shown to reduce rectal pain and this has been correlated to activation of the right prefrontal cortex, right insula and perigenual anterior cingulate cortex. Such central changes might explain the potential benefit of antidepressants in IBS. Twin studies and familial studies suggest that there is a genetic contribution to IBS, although the importance of this remains in dispute. A search for candidate genes continues, with the working hypothesis that environmental factors likely play an important role in the pathogenesis in the genetically primed individual.

Diagnosis of IBS is based on positive history of abdominal discomfort or pain associated with disturbed defecation, in the absence of obvious alarm features. It is no longer a diagnosis of exclusion; there is good evidence that a positive diagnosis is robust. Furthermore, current evidence does not suggest that blood tests, stool studies, abdominal imaging or endoscopy are required to make a diagnosis in the setting of positive symptoms and no alarm features. One area of controversy surrounds coeliac disease that can present with typical symptoms of IBS in the absence of weight loss or other obvious features. It is estimated that testing for coeliac disease serologically is cost-effective, assuming the prevalence of coeliac disease exceeds 8% in patients with IBS in local clinical practice.

Plant medicineprovides elimination of IBS by directly reducing gastrointestinal spasms, improving metabolic functionality, strengthening the immune system, and lifting emotions. Results achieved with this treatment are more than convincing especially in view of the poor efficacy of current available medications. Chemical drugs such as antibiotic used clinically can cause drug resistance of microorganism and parasite easily, thus reducing the sensibility to drugs. Abuse of antibiotic and other chemical drugs have already cut down the role of these antibiotics severely and produce new viruses consequently.

Application of chemical drugs aggravates chemical pollutions in the body, make body over-burdened and immune response wrong, and cause immune hypersensitivity; hence autoimmune diseases and immunodeficiency increases. Natural drugs come from plants or mineral of nature and their direct destruction aiming at infectious agent is often inferior to western medicine. However, natural drugs are not for destroying enemy but for mobilizing autologous tissue or self-recovery capability. Additionally, natural drugs have an effect to improve effect and decrease toxicity by compatibility of medicines and reduce side effect further.

The health care system of America has many drawbacks; the health care costs rise year after year; the economic burden is too high; additionally, western medicine and synthetic drugs are not a panacea and can not meet the requirements of the people. All these factors encourage them to find a new way. Many people in America don't have health insurance and taking medicine is a major economic burden for them. For IBS and other common diseases, it's the most economical choice to take plant medicine. To learn more, please go to .