A syringe manufacturers for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.
Claims
What is claimed is:

1. A syringe for use with a fluid, the syringe comprising: a barrel including a first opening, a second opening from which the fluid is dispensed, a sidewall between saidfirst and second openings, an inwardly-facing surface on said sidewall, and a plurality of axial grooves defined in said inwardly-facing surface, said inwardly-facing surface and said axial grooves configured to be contacted by the fluid, saidinwardly-facing surface centered about a longitudinal axis extending from said first opening to said second opening, and said axial grooves extending along said inwardly-facing surface substantially parallel to said longitudinal axis from a firstlocation on said inwardly-facing surface proximate to said first opening to a second location on said inwardly-facing surface proximate to said second opening; and a piston disposed inside said sidewall of said barrel to define a fluid chamber betweensaid piston and said second opening that is in fluid communication with said second opening, said piston having a periphery that provides a fluid seal with said axial grooves to inhibit fluid leakage from said fluid chamber between said piston and saidinwardly-facing surface as said piston is advanced toward said second opening to dispense the fluid from said fluid chamber through said second opening.

2. Thesyringe manufacturersof claim 1 wherein said axial grooves provide an average surface roughness greater than about 0.1 microns.

3. The syringe of claim 2 wherein said surface roughness is greater than about 2.5 microns.

4. The syringe of claim 3 wherein said surface roughness is between about 2.5 microns and about 5.1 microns.

5. The syringe of claim 1 wherein said sidewall has a flexibility and said axial grooves provide a level of said surface roughness to cooperate with said flexibility of said substantially cylindrical sidewall to reduce void formation.

6. The syringe of claim 5 wherein said sidewall is formed from polypropylene, and said substantially cylindrical sidewall has a thickness ranging from about 0.019'' and about 0.025''.

7. The syringe of claim 5 wherein said flexibility depends upon a thickness of said sidewall and a material forming said substantially cylindrical sidewall.

8. The syringe of claim 1 further comprising: a pressure sleeve capable of being placed in a surrounding relationship with said sidewall when the fluid is dispensed through said second opening.

9. The syringe manufacturers of claim 1 wherein said inwardly-facing surface of said sidewall and said axial grooves include a plurality of surface features configured to increase a surface area over which said inwardly-facing surface is contacted by thefluid.

10. The syringe of claim 9 wherein said surface features comprise a surface texture.

11. The syringe of claim 10 wherein said surface texture provides an average surface roughness greater than 0.1 microns.

12. The syringe of claim 10 wherein the surface roughness ranges from about 2.5 microns to about 5.1 microns.

13. The syringe of claim 1 further comprising: a fluid disposed within said barrel.

14. The syringe of claim 1 wherein said axial grooves extend substantially along the length of said sidewall.

15. Thesyringe manufacturersof claim 1 wherein said axial grooves have one of the following cross-sectional profiles: a) double shaped b) rounded U c) squared U d) hemispherical e) elongated f) V-shaped g) rounded V-shaped h) crescent shaped, and i)I-shaped.

16. The syringe of claim 1 wherein said axial grooves have a cross-sectional profile that increases a surface area over which said inwardly-facing surface is contacted by the fluid.

17. The syringe of claim 16 wherein said inwardly-facing is textured between said grooves to further increase the surface area over which said inwardly-facing surface is contacted by the fluid.

18. The syringe of claim 1 wherein said axial grooves extend along said inwardly-facing surface along an entire length of said sidewall.

19. The syringe manufacturers of claim 1 wherein said axial grooves have an average depth dimensioned so that the piston has the peripheral fluid seal that inhibits fluid leakage between said piston and said inwardly-facing surface as said piston movestoward said second opening.