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Aconitase could help protect against aging from a molecular standpoint.
A new and recent test was conducted in France that found a very special characteristic of a particular enzyme. This enzyme, or catalyst molecule, protects the mitochondria in times of elevated stress, and thus helps it provide a greater amount of energy to the body.
It also helps deter free radicals from allowing the antioxidants to cause accelerated aging in both younger and older populations. The project, conducted by a leading dermatologist named Dr. Nouha Domloge, demonstrated that the enzyme aconitase plays a crucial role in protecting the basic informational unit of the mitochondria, commonly known as our DNA.
Mitochondrial damage brung about by reactive oxygen species has been well documented in a wide range of animals and organisms. The process by which is mitochondrial protein gets specifically oxidized is still not completely understood by scientific and medical officialdom.
By medical definition, aconitase is a type of enzyme that catalyses the isomerization of the a substance called citrate. It basically turns citrate to isocitrate. It accomplishes this through the tricarboxylic acid cycle. In other words, aconitase is the material that initiates an isomerization process. Another enzyme that is part of the tricarboxylic acid cycle is malate dehydrogenase.
Medical researchers are suggesting that cis-aconitate, isocitrate, and citrate itself are highly related to the enzyme aconitase. Cis-aconitase is not necessarily given off at the surface of enzyme but is transformed into isocitrate right away.
Aconitase has been shown to control a resistance to oxidative processes in plants, and thus may help prevent the aging process. Scientists have discovered that aconitase helps stop cell death in Nicotiana and Arabidopsis types of laboratory testing plants.
Though the vast majority of iron-sulfur protein compounds function primarily as electron carriers, the iron the aconitase cluster deals directly the substrate of the enzyme.
The activity of aconitase is known to be hindered by fluoroacetate. For this reason, flouroacetate is considered by many people to a ver harmful and sometimes poisonous substance.
This tricarboxylic acid cycle is not a redox-active system, but the aconitase complex is highly vulnerable to oxidation by superoxide material. Oxygen radicals reduce our energy content and decrease the availability of free energy just about everywhere in our body, including our internal organs, and of course, our skin. Scientists examined this effect further when they recruited volunteers for tests that were induced under different types of stress.
They targeted fibroblasts, or cells that give rise to connective tissue, and found that by giving an aconitase-inducing active ingredient, also known as (AC) to the subjects, a significant increase in mitochondrial activity was noted. The viability of the mitochondria was also significantly elevated.
Benefits of protecting the mitochondria are endless, even from a molecular standpoint. Protecting the mitochondria in our cells means protecting our skins from the destructive effects of aging due to free radicals and antioxidants. Antioxidants are becoming increasingly popular when it comes to methods of preventing the human aging process References:
Moeder W, Del Pozo O, Navarre DA, Martin GB, Klessig DF. Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana. Plant Mol Biol. 2007 Jan;63(2):273-87. Epub 2006 Oct.
Niedworok, A. Bielaszka. Comparison of the effect of vitamins A and E on aging processes of edible vegetable Oils. Polish J. of Environ. Stud. 2007 Jun 17; 16 (6): 861-865 Note to Readers and Article Distributors:
Everyone is permitted to reprint, publish, post, and distribute this particular article on the web provided the author's bio and the hyperlinks contained therein are included.
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