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While most people often think of excess weight as a risk factor for diabetes, heart disease, sleep apnea, or osteoarthritis, an accumulating body of evidence now points to obesity an important risk factor for cancers. While previous studies have shown the importance of obesity as a risk factor for breast and colon cancers, a study by Arsian and colleagues from the Pancreatic Cancer Cohort Consortium (PanScan) published in the latest issue of theArchives of Internal Medicinesuggests that obesity may also be an important risk factor for pancreatic cancer. Using a nested case-control design that included 2170 cases and 2209 control subjects, the PanScan study found a positive 33% higher risk for pancreatic cancer in individuals with the highest compared to the lowest BMI quartile. This relationship was found both in men and women. When the researchers looked at abdominal obesity, the risk for pancreatic cancer in women in the highest quartile of waist circumference was almost twice that of women in the lowest quartile. These findings certainly provide strong support for a positive association between BMI and pancreatic cancer risk and suggest that centralized fat distribution may increase pancreatic cancer risk, especially in women. Given the observation that one of the most impressive impacts of bariatric surgery is an almost 60% reduction in cancer mortality, prevention of weight gain or successful weight management may certainly go a long way in reducing the risk of dying of this horrible disease. About Dr. Sharma: Dr. Sharma has authored and co-authored more than 250 scientific articles and has lectured widely on the etiology and management of obesity and related cardiovascular disorders. He sends his informative messages through his blog Dr. Sharma's Obesity Notes.
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