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Alzheimer's drug 'shows rapid language improvement' (21/07/2008) New study offers hope for further investigations. A novel immune-based approach in the treatment of Alzheimer's disease has apparently shown a rapid improvement in patients' language-based skills.
The anti-tumor necrosis factor-alpha (TNF-alpha) drug was shown to have a positive effect on verbal abilities within minutes of being administered, according to the research published today in the open-access journal BMC Neurology.
It is suggested by the researchers that increased levels of TNF-alpha seen in the brains of Alzheimer's patients interferes with the regulation of neural impulses.
Lead author of the study Edward Tobinick pointed out that the results have limitations as it was not a controlled trial, but added "the scientific rationale for the further investigation of anti-TNF-alpha treatment of Alzheimer's disease is compelling".
He said the behavioural and cognitive improvement associated with the medicine has been confirmed by independent observers and family members.
Meanwhile, a separate study published in the Lancet suggests a drug previously used as an antihistamine in Russia has shown encouraging results with Alzheimer's patients.
Researchers said Dimebon is the first Alzheimer's drug to show continued improvement in patients over a 12-month period. Article sourced from Barchester Care Homes Exercise 'may slow Alzheimer's progress' (15/07/2008) Study examines effects of fitness on progression of condition. New research suggests Alzheimer's patients with higher fitness levels have larger brains than those who are less physically fit.
The study published in the latest Neurology journal examined 121 people aged 60 and over, including 57 individuals in the early stages of Alzheimer's disease.
Researchers found the differences in brain shrinkage were linked to physical fitness and were not related to other variables such as gender, age and frailty.
Jeffrey M Burns, from the University of Kansas School of Medicine, said: "People with early Alzheimer's disease who were less physically fit had four times more brain shrinkage when compared to normal older adults than those who were more physically fit."
He went on to suggest people with early Alzheimer's may be able to preserve brain function for a longer period by taking regular exercise.
A separate study released yesterday by researchers from the University of New South Wales's school of psychiatry found the brain may shrink more quickly in people who carry out less-complex mental activity during their lifetimes.
Article sourced from Barchester Care Homes
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